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KMID : 0043320100330091325
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Archives of Pharmacal Research
2010 Volume.33 No. 9 p.1325 ~ p.1329
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The occurrence of 15-keto-prostaglandins in the red alga Gracilaria verrucosa
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Dang Hung-The
Lee Hye-Ja
Yoo Eun-Sook
Hong Jong-Ki
Choi Jae-Sue
Jung Jee-H.
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Abstract
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New 15-keto-prostaglandins (1?4) were isolated from the MeOH extract of the red alga, Gracilaria verrucosa. Their structures were determined to be prostaglandin B congeners (1?3) and a prostaglandin E congener (4) based on the NMR and MS data. Prostaglandins with a C-15 keto function are rare from natural sources. The presence of these metabolites in the alga is notable because 15-keto-prostaglandins (15-keto-PGs) are considered to be the metabolic products of regular prostaglandins in mammals. The occurrence of different prostaglandins in this alga might be due to the existence of different oxidative enzymes, as previously mentioned for oxygenated fatty acids of the red alga Gracilariopsis lemaneiformis. The antiinflammatory activity of these prostaglandins was examined by evaluating their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophage cells. These prostaglandins showed weak activity on nitric oxide production.
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KEYWORD
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15-keto-Prostaglandins, Nitric oxide, Gracilaria verrucosa
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